MOP "Emprendimiento de desarrollo e implementación de una plataforma financiera para jóvenes de 18 a 25 años en Lima Metropolitana 2022"

Durante el presente proyecto se ofrece al mercado un servicio orientado al sistema financiero de nuestro país. Este proyecto ofrecerá a todos los usuarios que se registren para brindarles información sobre los bancos, es decir, mediante una página web se ofrecerá la información sobre las tasas de los bancos como también ciertos beneficios que estos brindan, así para se pueda ayudar a los miembros a crear una fuerte comunidad mediante una red. Esta plataforma de página web se basara en 3 servicios diferentes mediante la suscripción, el primero que entra en la suscripción freemium es información sobre cómo se encuentra el sistema financiero en el Perú, asimismo noticias sobre la economía en el mundo para brindar al consumidor un “big picture” sobre la situación, luego en la misma sintonía se ofrecerá a los usuarios información sobre los bancos, cuáles son sus tasas, sus beneficios para que así cada usuario pueda analizar mejor sus opciones, por otro lado también se ofrece un servicio Premium que les ofrecerá todo lo anterior con el adicional de asesorías para tener un servicio más especializado. Por último, para poder validad todas las hipótesis que se han mencionada en el párrafo anterior se han realizado diferentes experimentos para poder tener un mejor entendimiento sobre el mercado objetivo y la segmentación de mercado, el cual ayudara a poder mejorar el modelo de negocio planteado. Luego de haberse realizado los experimentos se logró realizar algunas ventas logrando validar el negocio planteado exitosamente, esto servirá para poder analizar si que el proyecto es sostenible con el tiempo.During this project, a service oriented to the financial system of our country is offered to the market. This project will offer all users who register to provide them with information about banks, that is, through a web page information about bank rates will be offered as well as certain benefits that they provide, so that members can be helped to create a strong community through a network. This website platform will be based on 3 different services through subscription, the first one that enters the freemium subscription is information on how the financial system is in Peru, as well as news about the economy in the world to provide the consumer with a “ big picture” about the situation, then in the same vein users will be offered information about the banks, what their rates are, their benefits so that each user can better analyze their options, on the other hand a Premium service is also offered that It will offer all of the above with the additional advice to have a more specialized service. Finally, in order to validate all the hypotheses that have been mentioned in the previous paragraph, different experiments have been carried out in order to have a better understanding of the target market and market segmentation, which will help to improve the proposed business model. After having carried out the experiments, it was possible to make some sales, validating the business successfully proposed, this will serve to analyze whether the project is sustainable over time.Trabajo de investigació

Much Ado About Leptoquarks: A Comprehensive Analysis

We examine the phenomenological implications of a 200 GeV leptoquark in light of the recent excess of events at HERA. Given the relative predictions of events rates in e^+p versus e^-p, we demonstrate that classes of leptoquarks may be excluded, including those contained in E_6 GUT models. It is shown that future studies with polarized beams at HERA could reveal the chirality of the leptoquark fermionic coupling and that given sufficient luminosity in each e^\pm_{L,R} channel the leptoquark quantum numbers could be determined. The implications of 200-220 GeV leptoquarks at the Tevatron are examined. While present Tevatron data most likely excludes vector leptoquarks and leptogluons in this mass region, it does allow for scalar leptoquarks. We find that while leptoquarks have little influence on Drell-Yan production, further studies at the Main Injector are possible in the single production channel. We investigate precision electroweak measurements as well as the process e^+e^-\to q\bar q at LEP II and find they provide no further restrictions on these leptoquark models. We then ascertain that cross section and polarization asymmetry measurements at the NLC provide the only direct mechanism to determine the leptoquark's electroweak quantum numbers. The single production of leptoquarks in \gamma e collisions by both the backscattered laser and Weisacker-Williams techniques at the NLC is also discussed. Finally, we demonstrate that we can obtain successful coupling constant unification in models with leptoquarks, both with or without supersymmetry. The supersymmetric case requires the GUT group to be larger than SU(5) such as flipped SU(5)\times U(1)_X.Comment: Corrected single production cross section at Tevatron, updated atomic parity violation constraints, 55 page

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

Aging is a complex phenomenon involving functional decline in multiple physiological systems. We undertook a comparative analysis of skeletal muscle from four different species, i.e. mice, rats, rhesus monkeys, and humans, at three different representative stages during their lifespan (young, middle, and old) to identify pathways that modulate function and healthspan. Gene expression profiling and computational analysis revealed that pathway complexity increases from mice to humans, and as mammals age, there is predominantly an upregulation of pathways in all species. Two downregulated pathways, the electron transport chain and oxidative phosphorylation, were common among all four species in response to aging. Quantitative PCR, biochemical analysis, mitochondrial DNA measurements, and electron microscopy revealed a conserved age-dependent decrease in mitochondrial content, and a reduction in oxidative phosphorylation complexes in monkeys and humans. Western blot analysis of key proteins in mitochondrial biogenesis discovered that (i) an imbalance toward mitochondrial fusion occurs in aged skeletal muscle and (ii) mitophagy is not overtly affected, presumably leading to the observed accumulation of abnormally large, damaged mitochondria with age. Select transcript expression analysis uncovered that the skeletal inflammatory profile differentially increases with age, but is most pronounced in humans, while increased oxidative stress (as assessed by protein carbonyl adducts and 4-hydroxynonenal) is common among all species. Expression studies also found that there is unique dysregulation of the nutrient sensing pathways among the different species with age. The identification of conserved pathways indicates common molecular mechanisms intrinsic to health and lifespan, whereas the recognition of species-specific pathways emphasizes the importance of human studies for devising optimal therapeutic modalities to slow the aging process

Overexpression of CYB5R3 and NQO1, Two NAD\u3csup\u3e+\u3c/sup\u3e-Producing Enzymes, Mimics Aspects of Caloric Restriction

Calorie restriction (CR) is one of the most robust means to improve health and survival in model organisms. CR imposes a metabolic program that leads to increased stress resistance and delayed onset of chronic diseases, including cancer. In rodents, CR induces the upregulation of two NADH‐dehydrogenases, namely NAD(P)H:quinone oxidoreductase 1 (Nqo1) and cytochrome b5 reductase 3 (Cyb5r3), which provide electrons for energy metabolism. It has been proposed that this upregulation may be responsible for some of the beneficial effects of CR, and defects in their activity are linked to aging and several age‐associated diseases. However, it is unclear whether changes in metabolic homeostasis solely through upregulation of these NADH‐dehydrogenases have a positive impact on health and survival. We generated a mouse that overexpresses both metabolic enzymes leading to phenotypes that resemble aspects of CR including a modest increase in lifespan, greater physical performance, a decrease in chronic inflammation, and, importantly, protection against carcinogenesis, one of the main hallmarks of CR. Furthermore, these animals showed an enhancement of metabolic flexibility and a significant upregulation of the NAD+/sirtuin pathway. The results highlight the importance of these NAD+ producers for the promotion of health and extended lifespan

Search for SUSY with R-Parity Violation at gamma-proton and gamma-electron colliders

We present an outlook for possible R-parity violating SUSY search at gamma-proton and gamma-electron colliders. Single production of third generation slepton/sneutrino through the lambda'-ijk couplings at a gamma-p collider is investigated and compared with the results of the resonant sfermion productions at the existing colliders. Also single sneutrino production at a future gamma-electron collider through the lambda(ijk) couplings is disussed.Comment: 7 pages, 3 figures, enlarged version, a section adde

Metformin improves healthspan and lifespan in mice

Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic. Treatment with metformin mimics some of the benefits of calorie restriction, such as improved physical performance, increased insulin sensitivity, and reduced LDL and cholesterol levels without a decrease in caloric intake. At a molecular level, metformin increases AMP-activated protein kinase activity and increases antioxidant protection, resulting in reductions in both oxidative damage accumulation and chronic inflammation. Our results indicate that these actions may contribute to the beneficial effects of metformin on healthspan and lifespan. These findings are in agreement with current epidemiological data and raise the possibility of metformin-based interventions to promote healthy aging

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum